Detection of irinotecan using titanium nanoparticles modified electrode

Abstract

A tool has been developed in this study to estimate one of the Irinotecan (INR) cancer drugs used in the treatment of lung cancer by using square wave voltammetry (SWV) techniques, on surface of electrode graphite (GrE) and through of study the optimal condition that enhance the work of this electrode. The measurements are also enhanced by the electro-polymerization process of the neutral red pigment (NR) and using when presence of titanium nanoparticles (TiO_2NPs) to be greatly enhanced by measuring of LOD, LOQ and applied to human serum samples.

KEY WORDS: Irinotecan, Lung cancer, Square wave voltammetry, Titanium nanoparticles, Serum

Bull. Chem. Soc. Ethiop. 2020, 34(2), 227-236

DOI: https://dx.doi.org/10.4314/bcse.v34i2.2