Novel synthesis of pyrazole-containing thiophene, 2-alkyloxy-pyridine and thieno[2,3-d]pyrimidine scaffolds as analgesic agents

Abstract

ABSTRACT. A group of trisubstituted pyrazoles containing thiophen, 2-alkyloxypyridine and thieno[2,3-d]pyrimidine heterocycles were synthesized in a study for possible analgesic agents. The desired products were obtained by reaction of 2-((1-(3-chlorophenyl)-3-(4-methoxyphenyl)-1H-pyrazol-4-yl)methylene)malononitrile with sulfur in presence of TEA, followed by treatment with different reagents. Newer products were examined for their analgesic properties, among them, analog 7 showed significant analgesic effects in comparison with reference medicines activity.

KEY WORDS: Trisubstituted pyrazoles, Thiophene, Alkyloxypyridine, Fused pyrimidine, Analgesic activities

Bull. Chem. Soc. Ethiop. 2019, 33(3), 505-515. 

DOI: https://dx.doi.org/10.4314/bcse.v33i3.11