Antibacterial activity and pharmacological effect of some mixed-ligand tris-chelates of copper(II) containing neutral N,N-donors and kinetics study of the novel synthetic route for the complexes

Abstract

ABSTRACT. The present work describes in vitro antibacterial activities and pharmacological effect of six mixed-ligand tris-chelates of copper(II) containing N-p-tolylpyridine-2-aldimine; 1,10-phenanthroline and 2,2^'-bipyridine as neutral N,N-donors, towards some gram-positive and gram-negative bacterial strains in aqueous medium. All the six complexes have encouraging potentiality to inhibit the growth of some gram positive and gram negative bacteria and hence bacteriostatic agents. These copper(II) complexes were synthesized easily at room temperature by the novel silver(I) assisted trans-metallation reaction and kinetic study of the reactions suggest pseudo zero order.

KEY WORDS: Copper(II)tris-chelates, Neutral N,N-donors, Bacteriostatic agent, Silver(I) assisted reaction, Kinetics study

Bull. Chem. Soc. Ethiop. 2019, 33(3), 475-484.

DOI: https://dx.doi.org/10.4314/bcse.v33i3.8