Synthesis, X-ray analysis and antibacterial study of silver complex with ethyl-5-hydroxy- 2-oxo-2H-chromene-3-carboxylate

Abstract

ABSTRACT. A novel silver complex [Ag(C₁₂H₉O₅)₂] was synthesized by the reaction of silver salt (AgNO₃)and coumarin based ligand (ethyl-5-hydroxy-2-oxo-2H-Chromene-3-carboxylate) at room temperature. The synthesized complex was characterized by using different analytical techniques like melting point (mp), infrared (IR) spectroscopy, powder X-ray diffraction (PXRD), thermo gravimetric analysis (TGA), atomic absorption spectroscopy (AAS) and mass spectrometry (ESI-MS). Ligand showed activity with MIC 20 µg/mL, 15 µg/mL, 15 µg/mL for S. aurues, E. coli and S. typhi, respectively whereas MIC values of Ag-complex for above mentioned bacterial strains were found to be 15 µg/mL, 10 µg/mL, 10 µg/mL, respectively.  Ligand could not inhibit the growth of B. Subtilis, P. auruginosa, MRSA but Ag-complex showed MIC 30 µg/mL, 25 µg/mL for B. Subtilis and P. auruginosa. It also remained ineffective against MRSA.

KEY WORDS: Silver complex, Ethyl-5-hydroxy-2-oxo-2H-Chromene-3-carboxylate, Antibacterial study

Bull. Chem. Soc. Ethiop. 2019, 33(3), 467-474. 

DOI: https://dx.doi.org/10.4314/bcse.v33i3.7