Synthesis and cytotoxicity of novel thiophene, pyran and pyridine derivatives

Abstract

The reaction of 2-amino-3-cyano-tetrahydrobenzothiophene 3 with ethyl acetoacetate gave the amide derivatives 5. The reactivity of 5 toward a variety of chemical reagents was studied to give pyrans, pyridines, thiophenes and the thiazoles and their fused derivatives. The structures of the newly synthesized products were confirmed on the basis of their respective analytical and spectral data. The antitumor evaluations of the synthesized compounds against the three cancer cell lines MCF-7, NCI-H460 and SF-268 showed that compounds 9a, 9c, 12a and 14 were of the highest potencies against the three cancer cell lines among the tested compounds.

KEY WORDS: Tetrahydrobenz[b]thiophene, Pyran, Pyridine, Thiophene, Thiazole, Cytotoxicity

Bull. Chem. Soc. Ethiop. 2018, 32(2), 259-270.

DOI: https://dx.doi.org/10.4314/bcse.v32i2.7