Spectral characterization and DNA binding properties of lanthanide(III) complexes with 2-acetylpyridine isonicotinoylhydrazone (APINH)

Abstract

The lanthanide(III) complexes of  general  formula of [Ln(APINH)₂(NO₃](NO₃)₂.nH₂O (where,  Ln = La, Ce, Pr, Nd, Sm; APINH = 2-acetylpyridine  isonicotinoyl hydrazone, n = 0, 2 and 5 for La/Ce/Pr, Sm and Nd complexes, respectively) were synthesized under mild reaction conditions with excellent yields. The complexes were characterized based on elemental analysis, molar conductivity, and infrared spectroscopy. Molar conductivity data suggest that the complexes are 1:2 electrolytes. IR spectral data suggest that APINH acts as neutral tridentate ligand. Spectral data of complexes suggest that the ligand binds metal ion through pyridine-  nitrogen, azomethine-nitrogen and amido-oxygen donor atoms. Electrochemical behaviour of metal complexes was investigated by using cyclic voltammetry. The complexes undergo quasi-reversible one electron reduction. The binding interaction of complexes with CT-DNA was investigated using absorption spectrophotometry. Based on spectral changes, groove binding of complexes to DNA is suggested.

KEY WORDS: Lanthanide(III) complexes, 2-Acetylpyridine isonicotinoylhydrazone, Spectral characterization, DNA binding

Bull. Chem. Soc. Ethiop. 2016, 30(2), 221-230.

DOI: http://dx.doi.org/10.4314/bcse.v30i2.6