Synthesis of pyrimidine carboxamide derivatives catalyzed by uranyl nitrate hexa Hydrate with their antibacterial and antioxidant studies

Abstract

An efficient and simple method was developed for the synthesis pyrimidine-5-carboxamides using UO₂(NO₃)₂.6H₂O catalyst under conventional and microwave irradiation. The synthesis of dihydropyrimidine using uranyl nitrate had shown many advantages such as easy work up, shorter reaction times and higher yields using acetonitrile as a solvent. The structures of the synthesized compounds were confirmed by FT-IR, ¹H NMR, ¹³C NMR and mass spectral data. All the synthesized compounds screened for in vitro antioxidant and antibacterial activity and the results are reported.

KEY WORDS: Microwave, Uranyl nitrate, Antioxidant, Antibacterial

Bull. Chem. Soc. Ethiop. 2016, 30(1), 119-128. 

DOI: http://dx.doi.org/10.4314/bcse.v30i1.11