Voltammetric determination of tinidazole in pharmaceutical tablets using carbon paste electrode

Abstract

Cyclic voltammetry was used to study the electrochemical behavior of tinidazole at carbon paste electrode. Tinidazole showed an irreversible reduction peak at about -440 mV. The differential pulse voltammetric peak current of tinidazole showed linear dependence on concentration in the range 5.0-200 μM with LOD and LOQ of 5.1 10^-7 and 1.7 10^-6 μM, respectively. Relative to most of the reported works on the determination of tinidazole, the developed method using carbon paste electrode which is an environmentally friendly, cheap, and simple working electrode exhibited linear dependence of peak current on concentration in the lower concentration region with relatively low LOD. Excellent recovery results with low % RSD for spiked standard tinidazole in tablet samples showed the potential applicability of the developed method for the determination of tinidazole in real samples.

KEY WORDS: Carbon paste electrode, Differential pulse voltammetry, Tinidazole, Pharmaceutical tablets

Bull. Chem. Soc. Ethiop. 2016, 30(1), 1-12.

DOI: http://dx.doi.org/10.4314/bcse.v30i1.1