Flavonoids from the roots of Dioclea reflexa (Hook F.)

Abstract

Reflevone (1), a new flavone, together with, mearnsetin (2), 7,4'-dihydroxyflavone (3) and two known phytosterols, β-sitosterol (4) and stigmasterol (5) were isolated from ethanol soluble part of the roots of Dioclea reflexa (Hook F.). Their structures were elucidated by analysis of spectroscopic data involving 1D and 2D NMR, MS, IR and UV experiments. The crude roots extract showed significant activity with IC₅₀ = 5.18 µg/mL against the prostate cancer cell line.

KEY WORDS: Phytochemical analysis, Dioclea reflexa, Fabaceae, Cytotoxic activity, Flavonoid

Bull. Chem. Soc. Ethiop. 2015, 29(3), 441-448.

DOI: http://dx.doi.org/10.4314/bcse.v29i3.12