Synthesis and characterization and antibacterial activity of some new transition metal complexes with ciprofloxacin-imine

Abstract

Some new transition metal complexes of ciprofloxacin-imine derived from ciprofloxacin and o-phenylenediamine were synthesized and characterized on the basis of melting point, magnetic moment, conductance measurements, elemental analysis, infrared, UV/Vis, nuclear magnetic resonance spectroscopy, mass spectra as well as thermal analyses. The data indicate that the ligand acts as tetradentate chelate bound to the metal ions through the deprotonated carboxylate and the azomethine group. The ligand as well as their metal complexes was also evaluated for their antibacterial activity against several bacterial strains such as Staphylococcus aureus, Bacillus subtilis, Escherichia coli and Pseudomonas aeruginosa and also, fungicidal activity aganist Candida albicans and Aspergillus fumigatus were tested. It was found that the metal complexes are more antibacterial as compared to uncomplexes ligand and no antifungal activity observed for ligand and their complexes. Also, this study showed that the ciprofloxacin-imine is more antibacterial as compared to ciprofloxacin alone.

KEY WORDS: Shiff base, Metal complexes, TG, IR, Mass spectra

Bull. Chem. Soc. Ethiop. 2015, 29(2), 259-274

DOI: http://dx.doi.org/10.4314/bcse.v29i2.9