Spectroscopic, structural, thermal and antimicrobial studies of 4,6-bis (4-chlorophenyl)- 2-oxo-1,2-dihydropyridine-3-carbonitrile with some transition metals

Abstract

4,6-Bis(4-chlorophenyl)-2-oxo-1,2-dihydropyridine-3-carbonitrile (L) reacted with Mn(II), Fe(III), Co(II) and Ni(II) in methanol and acetone as a solvent at room temperature to form a new solid complexes. The isolated complexes were characterized by elemental analysis, magnetic properties, conductance measurements, mass, IR, UV-Vis and ¹H NMR spectroscopic methods and thermal analyses. The thermogravimetric and infrared spectroscopic data confirmed the presence of water in the composition of the complexes and the ligand reacted as a bidentate. The metal – ligand binding in metal complexes is predicted using density functional theory. The ligand and their metal complexes were also evaluated for their antibacterial activity. The complexes showed high activities compared with free ligand.

KEY WORDS: Pyridine derivative, 4,6-Bis(4-chlorophenyl)-2-oxo-1,2-dihydropyridine-3-carbonitrile, Transition metal complexes, Antibacterial activity

Bull. Chem. Soc. Ethiop. 2015, 29(1), 75-94

DOI: http://dx.doi.org/10.4314/bcse.v29i1.7