Infrared spectra, thermogravimetric analysis and antifungal studies of noval Cr(III), Fe(III) and Cu(II) 2-methyl-quinazolinone complexes

Abstract

Some new solid complexes [CrCl₃(L)₃]×6H₂O, [FeCl₃(L)₃]×6H₂O and [Cu(CH₃COO)₂(L)₃]×2H₂O have been synthesized quantitatively by the interactions of 2-methyl-quinazolinone (L) with CrCl₃.6H₂O, FeCl₃.6H₂O and Cu(CH₃COO)₂.2H₂O in a mixture of an ethanol-bidistilled water (1:1), at 60 °C. They were characterized by melting point, molar conductivity, magnetic moment, elemental analysis, infrared spectra and thermal analyses. The results supported the formation of the complexes and indicated that the ligand reacted as a monodentate ligand bound to the metal ion through the oxygen atom. The antifungal activity of the free ligand and their metal complexes were evaluated against several species, such as Fusarium solani, Rizoctonia solani, Sclortium rolfsii and Botryodiplodia and they showed a good antifungal activity to some selected fungal strain as compared with free ligand.

KEY WORDS: Quinazolinone; Cr(III); Fe(III); Cu(II); Antifungal activity, Thermal analyses

Bull. Chem. Soc. Ethiop. 2014, 28(1), 53-66.

DOI: http://dx.doi.org/10.4314/bcse.v28i1.7