Effect of <i>Eremina desertorum</i> eggs on hepato-renal toxicity induced by cisplatin drug

Abstract

Cisplatin (Cis) is a chemotherapeutic drug that has been used in the treatment of various types of cancers. However, the drug showed  various toxic side effects on vital organs. This study aims to investigate the hepato-renal protective effect of Eremnia desertorum eggs  powder (EDEP) in Ehrlich Ascites Carcinoma (EAC) bearing mice treated with Cis. Five groups of female Swiss albino mice were allotted as  follows: Group (Gp1) served as a negative control, Gp2-Gp5 had inoculated intraperitoneally (i.p) with 1×10⁶ EAC cells/mouse. Then, Gp2  was left without treatment as a positive control (EAC-bearing mice). After 24 hours, Gp3, and Gp4 had injected i.p. with Cis (2 mg/kg)  EDEP (500 mg/kg) daily for 7 consecutive days, respectively. Gp5 was injected with a combination of Cis/EDEP as in Gp3 and Gp4. All  treated groups were sacrificed at day 12, and the percentage of the body weight changes (%b.wt), tumor indices, haematological and  biochemical parameters, and antioxidant /oxidant biomarkers as well as histological alterations of liver and kidney tissues were  investigated. The results showed that the % b.wt changes were increased in EAC-bearing mice and EAC-bearing mice that were treated  with EDEP. While, the treatment of EAC-bearing mice with Cis decreased the % b.wt changes. The treatment of EAC-bearing mice with a combination of Cis/EDEP led to an improvement in AST, ALT, urea, creatinine, antioxidant enzyme activities, and ameliorated the    histopathological toxicities in the liver and kidneys in EAC-bearing mice.