Effect of antiretroviral therapy on some liver enzymes in HIV/AIDS breast fed and non breast fed children

Abstract

The relationship and effect of antiretroviral therapy with associated hepatotoxicity were investigated in different paediatric age groups using serum alanine and aspartate transaminases (ALT and AST) and alkaline phosphates (ALP) biomarkers. The study consisted of a total of one
hundred and twenty (120) participants; fifteen (15) each from different age groups of HIV infected children at baseline and three (3) months after initiation of therapy as well as a control group. Ninety three percent (93%) of the children studied acquired HIV infection through vertical transmission with seventy percent (70%) having mixed feeding as their feeding pattern. Before treatment initiation, total serum ALT and AST values (mean±S.E.M.) (25.7±4.8 and 69.6±3.6 U/L) were significantly higher (p<0.05) among the baseline than the control groups (21.1±1.9 and 17.9±3.6 U/L). After treatment, total serum transaminases and ALP values were found to be

significantly lower (p<0.05) among the treated (24.4±3.6, 38.4±5.4 and 255.5±77.5 U/L) than the baseline (25.7±4.8, 69.6±3.6 and 262.1±114.8 U/L) groups, except for the children in the least age group. This study concluded that antiretroviral drugs have effect on liver enzymes and are risk factors for developing hepatotoxicity especially in children at lower age groups. Children therefore require frequent evaluation during antiretroviral therapy even in the absence of signs and symptoms of metabolic complications.

Keywords: Antiretroviral therapy, hepatotoxicity, transaminases, paediatric.