Effect of Calitropis Procera Aqueous Root Extract Against CCL4 Induced Liver Toxicity in Rabbits

Abstract

The hepatocurative effect of aqueous root extract of Calitropis Procera on CCl4 induced hepatotoxicity in rabbits was studied in groups of rabbit and the levels of liver enzymes; aspartate amino transferase (AST), alanine amino transferase (ALT) and alkaline phosphatase (ALP). Serum concentrations of total bilirubin and direct bilirubin were found to be significantly (p<0.05) higher in group induced with hepatotoxicity, with significantly (p<0.05) lower total protein and urea compared to the control group. These findings confirmed induction of hepatotoxicity. Three different dosages were orally administred (1.0g/kg, 2.5g/kg and 3.6 g/kg) twice daily for 9 days. The C. Procera root extract was found to significantly (p<0.05) reduce the serum levels of AST, ALT, and ALP, serum concentration of total bilirubin in rats with hepatotoxicity compared to the the control group and significantly (p<0.05) incerased the serum concentration of total protein and urea. These indicates the possible hepatocurative effects of aqueous root extract of C. Procera on CCl₄ induced liver toxicity.