Sub-Acute Hepatoxicity of Aqueous Leaf Extract of Eucalyptus camaldulensis in Rats

Abstract

Sub–acute toxicity study of the aqueous leaf extract of Eucalyptus camaldulensis was carried out on albino rats. Doses of 250mg, 500mg, 750mg and 1000mg per kilogram body weight of the extract were administered orally for 21 days. The activities of Alanine Aminotransferase (ALT), Aspartate Aminotransferase (AST), Alkaline Phosphatase (ALP) and the concentrations of total protein, and unconjugated bilirubin in the serum of the experimental rats were determined. The results obtained showed no significant difference (P>0.05) when compared to the control rats that were not administered the extract in all the parameters determined. The results indicated that, aqueous leaf extract of Eucalyptus camaldulensis may not have any toxicological effect at the administered doses.

Keyword: Eucalyptus camaldulensis, alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase, unconjugated bilirubin.