Evaluating the effect of spherical crystallization of acetylsalicylic acid crystal and crystal agglomeration of Manihotesculenta starch on direct compression tablet properties

Abstract

Spherical crystallization and crystal agglomeration have been used to optimize compact crystals and functional properties of powders. The aim of this work is to evaluate the effect of spherical crystallization of acetylsalicylic acid crystals and crystal agglomeration of Manihotesculenta starch on direct compression tablet. Typical spherical crystallization using three solvent system of water–ethanol-carbon tetrachloride was used to produce spherical acetylsalicylic acid. Salting-out agglomeration of gelling in water and salting in ethanol was used to produce starch-xerogel from Manihotesculenta starch. The modified products were qualified using FT-IR analysis. The analysis results showed that modification did not alter chemical nature of the products. Acetylsalicylic acid tablets were formulated using spherical-crystallizedacetylsalicylic acid with 5 and 10% ^w/_w starch-xerogel respectively, and using acetylsalicylic acid with 5 and 10% ^w/_w of starch, and microcrystalline cellulose respectively. The physicochemical properties of the tablets were evaluated. Astatistical 2³ factorial design of the tablet properties at 5% level of significance showed that the effects of the variables are different. Theacetylsalicylic acid tablets formulated from direct compression of spherical-crystallizedacetylsalicylic acid with 5 % ^w/_w starch-xerogel produced quality tablets comparable to standard tablets from direct compression of acetylsalicylic acid with10 % ^w/_w microcrystalline cellulose. Spherical crystallization and crystal agglomeration optimized the compact crystals of starch and acetylsalicylic acid, and improved direct compression properties of the crystals, and drug release from tablet.