A survey on drug related problems in cervical cancer patients receiving chemotherapy in Ahmadu Bello University Teaching Hospital Zaria

Abstract

A drug-related problem (DRP) is an event or circumstance involving drug therapy that actually or potentially interferes with desired outcome. The complexities in drug regimens used in cervical cancer chemotherapy has led to more serious problems. The aim of this study is to investigate DRPs in cervical cancer patients receiving chemotherapy. The study was a retrospective cross sectional study on patients receiving cervical cancer chemotherapy at Ahmadu Bello University Teaching Hospital Zaria (ABUTH). Patients’ medication charts were reviewed from July, 2015 to June, 2016. Data were collected using the Pharmaceutical Care Network Europe (PCNE) Classification of DRP V 6.20. A total of 224 DRPs cases were identified from 65 cervical cancer patients. The DRPs were mostly on treatment effectiveness (28.1%), adverse reaction (29.0%), and cost (26.8%), while the causes were majorly drug selection (28.1%) and dose selection (29.0%). The risk factors for the DRPs were found to be comorbidities and polypharmacy. In conclusion, DRPs were common among cervical cancer patients receiving chemotherapy at ABUTH. Pharmacist interventions to achieve a better therapeutic outcome are necessary.

Keywords: Cervical cancer, chemotherapy, drug related problem, pharmacist, polypharmacy