The beneficial role of resveratrol on chlorpyrifos-induced cognitive impairment and lipid peroxidation biomarker in Swiss albino mice

Abstract

Chlorpyrifos (CPF) has been associated with cognitive and psychomotor impairments in both humans and animals. This cognitive impairment has been linked to its enhanced reactive oxygen species (ROS) generating capacity. Therefore, antioxidant treatment may provide a novel therapeutic window for the management of these related impairments. The aim of this work was to evaluate the beneficial role of resveratrol on chlorpyrifos-induced cognitive impairment and lipid peroxidation biomarker in Swiss albino mice. Swiss albino mice were divided into (6) six groups of five each (n=5). Group I served as the control and were administered olive oil (2 ml/kg), group II received carboxymethylcellulose (CMC) 10 mg/kg, group III received resveratrol 30 mg/kg, group IV received chlorpyrifos (CPF) 3 mg/kg, group V received CPF (3 mg/kg) after the oral administration of resveratrol (30 mg/kg) and group VI received Vitamin E (Vit E) 100 mg/kg All administrations were done by oral gavage for a duration of 21 days. Cognitive function was assessed using Y-maze,and Novel object recognition tests and oxidative stress was evaluated using oxidative biomarkers techniques.The results obtained showed that resveratrol at dose 30 mg/kg significantly(p<0.05) improved cognitive impairment and significantly decreased (p<0.05) malondialdehyde (MDA) concentration when compared with the control. In conclusion, 30mg/kg resveratrol suppressed memory impairment, decreased malondialdehyde levels, increased catalase activity, superoxide dismutase activity and glutathione levels in our chlorpyrifos-induced cognitive impairment mice model.

Keywords: cognition, chlorpyrifos, resveratrol, memory