The effect of aqueous stem bark extract of Erythrina mildbraedii on acetaminophen induced nephrotoxicity in rats

Abstract

This study was carried out to determine the curative effect of aqueous stem bark extract of Erythrina  mildbraedii in rats induced with nephrotoxicity using  800mg/kg Acetaminophen. Acetaminophen  administration resulted in significant increase in the serum level of urea, creatinine, Na⁺, K⁺, Cl^- and a  significant  decrease in the level of HCO₃ - . Administration of different doses (50, 100, & 150mg/kg) of aqueous stem bark extract of Erythrina mildbraedii ameliorated the  effect of Acetaminophen indicated by a significant  decrease in the level of urea, creatinine, Na⁺, K⁺ , Cl^- and an increase in the level of HCO₃ - when compared to  control rats. The histopathology showed a restoration of the renal architectures after administration of the  aqueous stem bark extract.

Keywords: Acetaminophen, Erythrina mildbraedii, nephrotoxicity, aqueous extract.