Sub-chronic toxicological studies of transition metal complexes of naproxen on sprague-dawley rats

Abstract

Objective: The purpose of this research was to investigate sub-chronic toxicity in animal model.
Methods: A detailed study was done on the physical, hematological, biochemical and hormonal parameters of both male and female Sprague-Dawley rats after 28 days administration of naproxen and its metal complexes.
Results: There were no significant changes found in physical parameters on observation for both male and female rats without some minor differences. However, Naproxen metal complexes showed comparatively lower side effects than naproxen. Hematological report suggested that naproxen was in process of initiating inflammation which was justified by decreasing the mean value hemoglobin and hematocrit level and increasing the white blood cells level. There were no significant changes in biochemical parameters, however, the mean value of blood glucose level and cholesterol seemed to be higher and triglyceride was lower. Thyroid hormone levels were found lower, that was another indication inflammatory process. However, this might have the ability to lower the insulin secretion resulting in increasing blood glucose level.
Conclusion: In the present investigation, there were no significant alterations in histopathological studies and physical parameters though some signs of abnormalities had been found but hematological and hormonal data did not suggest any inflammatory or toxicological activity. However, we observed that naproxen showed more side effects than metal complexes which indicated that carboxylic group (ACOOH) of naproxen may be responsible for showing those most of the side effects.