Glucose tolerance in Bufo gutturalis (Power) after destruction of the islets of Langerhans

Abstract

An investigation was undertaken to determine the glucose tolerance response in Bufo gutturalis after alloxan induced diabetes. The pancreatic β-cells were completely destroyed 24 h after the administration of 240 mg alloxan/kg body mass. However, animals treated In this manner showed a normal response curve. When the alloxan dosage and treatment period were Increased, typically diabetic tolerance was apparent.