Alteration of ABH Blood Group Antigens in a Patient with Acute Leukaemia

Abstract

The loss or weakening of an individual’s blood group due to disease is a rare phenomenon, which occurs more with myeloid malignancies. We report here the loss of the A antigen in an 18 year old boy treated for acute lymphoblastic leukaemia with a combination of Cyclophosphomide, Oncovin, Cytosine Arabinoside and predisolone. At first hospital admission he was typed as AB RhD positive but four months later he was typed as B RhD positive.