Non Secretory Multiple Myeloma in a Nigerian: A Case Report

Abstract

Non secretory multiple myeloma is a rare variant of multiple myeloma characterized by the absence of paraproteins in the serum/or urine. It may present a diagnostic challenge, hence the need for a high index of suspicion while excluding multiple myeloma as a cause of bone pain and lytic lesions. The objective of this study was to report a case of non secretory myeloma, which has not been previously reported in a Nigerian. A 55year old female teacher presented with a 2 month history of painful swelling on the sternum, with no antecedent trauma. Bone marrow aspiration cytology and skeletal surveys revealed plasmacytosis and multiple osteolytic lesions, respectively. Urinary and serum paraproteins were not detected; neither was Cyclin D1 over expression. She was managed as a case of non secretory multiple myeloma with good response to therapy.