Pyogenic Granuloma‑Like Kaposi’s Sarcoma

Abstract

Kaposi sarcoma (KS) has different clinicopathological presentations, an uncommon form of which is pyogenic granuloma (PG)‑like Lesions. This may make its diagnosis challenging, due to its clinical and histological features of both PG and KS. These skin lesions are superficial and protrude outward with subsequent ulceration and secondary infection giving the appearance of a PG. It has been reported in HIV‑negative and HIV‑positive KS patients. We report a 37‑year‑old HIV‑positive patient on highly active antiretroviral therapy with multiple flesh‑coloured skin growths, after initial clinical evaluation, a diagnosis of PG was initially made, however, skin biopsy of the growths revealed KS. We report this case because of rarity of this clinicopathological variant of KS, to which most clinicians misdiagnosed as PG (a benign lesion) with antecedent consequences of delayed treatment. Thus, there is a need for clinicians to do early tissue biopsy of skin growths in HIV/AIDS subjects in order not to miss this rare variant of KS.