Clinicopathological Analysis of Prostatic Lesions in a Tertiary Hospital in Nigeria

Abstract

Background: Prostatic neoplasms are important source of morbidity and mortality among men globally. A rising trend is noted worldwide especially involving sub-saharan African males where paradoxically data is grossly inadequate. We hereby present prostatic lesions from a tertiary center in sub-saharan Africa. Materials and Method: A retrospective analytic study of all prostatic samples received in the histopathology of National Hospital Abuja (NHA), a tertiary hospital in Nigeria, from 1st January 2005 to 31st December 2015 was carried out. Result: The major affected age group is the 61-70 year cohort. Majority of neoplastic lesions encountered are malignant adenocarcinomas of moderate differentiation. The predominant presenting symptoms are dysuria, frequency, and acute urinary retention in that order, while raised prostatic specific antigen (PSA) is a frequent sign. Conclusion: Prostatic adenocarcinoma is significant malignancy in NHA while benign prostatic hyperplasia is the commonest benign lesion. Gleason scores 5 and 7 are the predominant malignant differentiation obtained.