Modulatory effects of chronic ethanol ingestion on hepatotoxicity-related parameters in male rats

Abstract

5 g of ethanol (20% w/v) per kg body weight was administered to ten rats weighing between 166 – 170 grams daily for 28 days along side with normal feeds and water ad libitum. The administration of ethanol was done orally using oral catheter. A control group o ten rats was set up for a proper experimental evaluation. Analysis at the end of the adminstration showed tha ethanol in a dose of 5g/kg body weight significantly modulates (P<0.05) the activities of selected liver enzymes: alanine amino transferase (ALT), aspartate amino transferase (AST), gamma glutamyl transferase (GGT) and alkaline phosphatase (ALP) as well as those of selected antioxidant enzymes: catalase (CAT) and superoxide dismutase (SOD).

Keywords: Rats, Ethanol, Oral administration, Catheter, Liver, Hepatotoxicity, Antioxidant enzyme