Antipsychotic effect of aqueous stem bark extract of Amblygonocarpus andongensis in Wistar albino rats

Abstract

The study of antipsychotic efect of the aqueous stem bark extract of Amblygonocarpus andongensis was carried out on amphetamine induced psychosis in 42 Wister albino rats weighingbetween 105 and 3052g using two indices feeding and locomotor activity. Twelve out of the 42 rats were divided into two groups; six per group. Group 1 and 2 received 15mg/kg body weight ooral amphetamine. Oral chlorpromazine (0.5mg/kg) was administered to group 2 rats in additon The remaining 30 rats were divided ino 5 groups: A, B, C, D and E, each group comprised 6 rats. All the groups received 15 mg/kg body weight of amphetamine but E received 05mg/kg oral chlorpromazine in addton. However, B, C and D received 450, 900 and 1350mg/kg bodyweght of Amblygonocarpus andongensis aqueous stem bark extract. Feeding and locomotor activities were measured in groups 1 and 2 and A, B, C, D and E rats respectively. The result showed that there were significant diferences in feeding and locomotor parameters between groups 1 and 2 and among groups A, B, C and E (p<0.05) except group E. In amphetamine psychotic model test, group2 animals have reduced feeding and locomotor activity as compared to group 1. Conclusively, Amblygonocarpus andongensis has a dose dependent reducing effect on feeding and locomotor activity at 135mg/kg body weght as compared to chlorpromazine (0.5mg/kg) in amphetamine induced psychosis in Wister albino rats. Hence both Amblygonocarpus andongensis andchlorpromazine may have pharmacokinetic effect on amphetamine and therefore maybe used to treat psychosis induced by amphetamine.

Keywords: Antipsychotic, effect, Amblygonocarpus, andongensis, Wister rat