Effects Of Alcohol On Oxidative Parameters Of Alloxan Induced Diabetic Albino Rat

Abstract

The effects o alcohol consumption on lipid peroxidation and antioxidant status were investigated in the alloxan induced dabetic rats. Plasma from the diabetic rats not treated with alcohol (DNT); diabetic rats treated with alcohol (DT) and non diabetic rats (ND) were analysed for their malondialdelyde (MDA) and vitamin C levels. Both the glucose level and the body weightwere alsostudied. The mean weights o the rats in the diferent groups were the same until the onset o diabetes and alcohol ingestion when the weight decreased. After nine (9) days of alcohol suppementaton, the DT rats weighed114.00 ± 0.41 g and the DNT rats weghed 121.00 ± 1.22 gwhile the rats in the controlled group weighed 146.33 014 g. The glucose levels for DT, DNT and ND were 29.56, ± 0.56, 28.81 ± 0.87 and 5.42 ± 0.19 nmol/ respectvely. Analyss of the lipd peroxidaton product (MDA) obtained showed a significant (P < 005) increase in MDA values from – DT rate (38.63 ± 3.88) nmol/ml to DNT rats (2863 ± 1.38 nmol/lml), whle MDA value for ND rats was 7.88 ± 1.38 nmol/l. Plasma vitamin C vaues of 0.62 ± 0.05 mg/100ml 1.107 \" 0.13 mg/100ml and 1.79 ± 0.15 mg/100mlor DT, DNT and ND respectvely were obtaned.

Keywords: Alcohol, Antioxidant, Lipid peroxidation, Diabetes, Rat

Animal Research International Vol. 3 (3) 2006 pp. 570-572