Effects Of Aqueous Leaf Extract Of Vernonia Amygdalina On Blood Glucose And Triglyceride Levels Of Alloxan–Induced Diabetic Rats (Rattus rattus)

Abstract

The effect of Vernonia amygdalina aqueous leaf extract on serum glucose and triglyceride level of diabetic rats were investigated. The aqueous extract was administered to alloxan –diabetic rats. The bood glucose and serum triglyceride levels were estimated at time intervals post oral administration of the extract (80 mg/kg). The extract caused significant (P<0.05) and progressive time dependent reduction of blood glucose and serum triglyceride levels in both normoglyceamic and alloxan-induced diabetic rats, with similar time course of action. In conclusion, the significant reduction in bood glucose and serum triglyceride level observed in this study may help in alleviating some of the complications associated with diabetic conditions.

Keywords: Vernonia amygdalina, Leaf extract, Blood glucose, Serum triglyceride, Diabetic rats

Animal Research International Vol. 1 (2) 2004 pp. 90-94