Effects of roasted Senna occidentalis seeds on the haematology, hepatorenal functions and histopathology of albino rats

Abstract

The objective of this study is to evaluate the toxicological effects of aqueous extract of roasted Senna occidentalis seeds in rats. The acute toxicity was performed according to Lorke’s method. For the evaluation of the effects of roasted S. occidentalis seeds on the haematology, hepatorenal functions and organ histopathology of albino rats, 24 adult male and female rats were divided into four groups of twelve (six males and six female) rats each respectively as follows: 1 (control group given only water), 2 (0.1.0% S. occidentalis seed powder), 3 (0.5% S. occidentalis seed powder), and 4 (1.0% S. occidentalis seed powder). Changes in body weight and food consumption as well as death were observed. In addition, the haematology, kidney and liver function, as well as the histological features, were evaluated. The results showed that S. occidentalis roasted seed extract did not cause mortality or behaviour alterations in the rats. There were no significant changes in body weight, food consumption, biochemical and haematological parameters as well as tissue histology in the test groups compared to the control rats. Based on these findings, it can be concluded that S. occidentalis roasted seed extract did not cause significant changes in most of the parameters evaluated, suggesting its potential safety for consumption.