Effects of resveratrol on lipid profile of diabetes mellitus wound healing of male Wistar rats

Abstract

There is a growing body of research showing the potential health benefits of resveratrol, including anti-inflammatory and antioxidant properties. This study investigates the potential effects of resveratrol on lipid profile and its impact on wound healing in a Male  Albino Wistar Rats model of type 2 diabetes. 24 Male Albino Wistar Rats were rendered diabetic using a high-fat diet and an Alloxan injection. The rats were grouped into 4: Nondiabetic Control Group A (negative control), Diabetic Control Group B (positive control), Diabetic Treatment Group C (10 mg/kg resveratrol), and Diabetic Treatment Group D (20 mg/kg resveratrol). Excisional wounds were created on the dorsum of the rats and monitored for wound closure over a defined treatment period of 14 days. Body weight and fasting blood glucose levels were measured after the procedure and after the treatment respectively. Blood samples were collected on the 15th day by cardiac puncture to assess lipid profile parameters. Resveratrol administration positively modified body weight, blood glucose, and lipid profile, reducing total cholesterol, triglycerides, low-density lipoprotein, and elevation of high-density lipoprotein levels. Resveratrol supplementation not only enhanced wound healing but also alleviated dyslipidaemia in type 2 diabetic albino male rats, a common complicating factor in the management of diabetic wounds. These results imply that resveratrol might have a broad range of therapeutic applications in treating lipid profile abnormalities linked to type 2 diabetes as well as wound healing complications.