Renal function outcome in isoprenaline induced myocardial Infarction in albino rats and protective effect of methanol leaves extract of Jatropha tanjorensis

Abstract

Chronic kidney disease is prevalent among patients with myocardial infarction. There is positive correlation between renal dysfunction and myocardial infarction which could result to increase mortality in acute myocardial infarction patients. This present study evaluated the renoprotective effect of methanol leaves extract of Jatropha tanjorensis in isoprenaline induced myocardial infarction in albino rats.  Seventy two male albino rats were used for the in vivo study and randomly divided into six groups of twelve rats per group. Group 1 served as the normal control, group 2 was the negative control (administered 85 mg/kg of isoprenaline only), group 3 served as the positive  control (pretreated with 2 mg/kg carvedilol for 28 days, group 4 through 6 were pretreated with 200, 400 and 600 mg/kg of the extract  respectively for 28 days. Myocardial infarction was induced in the rats using subcutaneous injection of 85 mg/kg isoprenaline (ISO) for two consecutive days (26th and 27th) at 24 hours interval. The result of the in vivo study showed that isoprenaline significantly (p<0.05) produced alteration in the renal function integrity because there was significant (p<0.05) increase in urea, creatinine and altered kidney morphology of the negative control group compared to the 400 mg/kg extract treated groups. The extract at the dose of 400 mg/kg significantly (p<0.05) decreased the urea and creatinine level and maintained the kidney morphology. This study suggested that the extract at moderate dose could serve as an agent for the prevention of isoprenaline induced renotoxicity followed myocardial infarction.