Restoration potential of Celosia argentea leaf on acetaminophen-induced liver toxicity

Abstract

This work was aimed at determining the protective effect of Celosia argentea aqueous leaf extract on acetaminophen induced liver attack in male albino rats. A total of 42 rats were divided into seven groups of six rats with the leaf extract of C. argentea administered for eight days at 200 and 400 mg/kg in groups 4, 5, 6 and 7. Acetaminophen (3 g/kg) was administered to rats in group 2, 3, 6 and 7 on the eight day. Forty-eight (48) hours after Acetaminophen was administered, the rats were sacrificed and blood collected for aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP), total protein (TP) and serum albumin (SA) as well as histopathological analysis. The results showed that acetaminophen at 3 g/kg altered liver function, synthetic and pathological state whereas C. argentea leaf restored liver function toward normalcy thus making revealing hepatotoxic nature of acetaminophen and the hepatoprotective potential of C. argentea leaf.

Keywords: Acetaminophen, Celosia argentea, Aqueous leaf extract, Liver, Toxicity, Rat