Effect of ethanolic extract of Rosa canina on some serum biochemical parameters of diabetic male rats

Abstract

The aim of the present study was to investigate the effect ethanolic extract of Rosa canina on some serum biochemical factors of diabetic male rats. Thirty two (32) male Wistar rats weighting 200 – 250 grams in 4 groups (control, diabetic control, diabetics + 250mg/kg/day extract, diabetics + 500 mg/kg/day extract) were used. Diabetes was induced by STZ (60mg/kg) intraperitoneal injection. The period of experiment was 4 weeks. At the end of experiments, the rats were sacrificed and their serums collected for glucose, creatinine, urea and albumin estimation. The results showed that glucose, creatinine and urea concentrations were significantly increased in the diabetic group (p<0.05), while the serum albumin concentrations was reduced. The levels of glucose, creatinine and urea in treated groups decreased significantly in comparison with the diabetic control group (p<0.05). But albumin concentrations showed no significant changes (p>0.05). The changes of glucose in treatment groups showed no significant differences (p>0.01).

Keywords: Streptozotocin, Diabetic male rat, Rosa canina, Serum glucose, Creatinine, Albumin, Urea