Hematological and Serum Biochemical Parameters of Weanling Dogs Treated with Medroxyprogesterone Acetate

Abstract

The objective of this study was to determine the dose-dependent effect of medroxyprogesterone acetate on hematology and serum biochemistry in weanling dogs. Nine healthy local dogs between 12 to 14 weeks of age were randomly assigned to three treatments: control, 150mg/kg and 300mg/kg of medroxyprogesterone acetate. At the end of the 3-weeks experimental period, blood samples were collected and analyzed. Packed cell volume (haematocrit), hemoglobin concentration and serum protein were higher (p<0.05) in the treated dogs as compared with the control. No significant differences (p>0.05) were observed for the other parameters studied. The values were however, within normal reference values suggesting that the synthetic progestagen had no deleterious effect on serum biochemistry and hematology of weanling dogs.