Case Report: Central Diabetes Insipidus, Central Hypothyroidism, Renal Tubular Acidosis and Dandy‑Walker Syndrome: New Associations

Abstract

Dandy‑Walker syndrome (DWS) is a rare brain malformation involving the cerebellum, and the fluid filled spaces around it, usually detected during the antenatal period or the early infancy. Clinically, it is characterized by mental retardation, developmental delay as well as cerebellar ataxia. It has been frequently associated with other conditions such as congenital heart diseases, primary hypothyroidism, and other disorders of the central nervous, gastrointestinal, genitourinary, and orthopedic systems. In this report, we describe a 3‑month‑old Saudi boy with the rare association of DWS with central diabetes insipidus, congenital central hypothyroidism, and type‑2 renal tubular acidosis. 

Keywords: Central, Dandy‑Walker, Diabetes insipidus, Hypothyroidism, Renal, Tubular acidosis