A Study of Insulin Resistance and its Clinico.Metabolic Associations Among Apparently Healthy Individuals Attending a Tertiary Care Hospital

Abstract

Background: Insulin resistance (IR), as a result of unhealthy life.styles and westernization, most likely contributes to the increased incidence of metabolic abnormalities and consequently, the development of metabolic syndrome (MS).

Aim: The present study was undertaken to determine the magnitude of IR and associated clinico.metabolic risk factors among the out-patients of a tertiary care hospital in Bihar, India.

Subjects and Methods: Anthropometric profile, lipid profile, fasting blood glucose, C-reactive protein (CRP) and C-peptide of 112 individuals were measured using the standard procedures. IR was assessed using the homeostasis model (Homeostatic model assessment [HOMA]-IR).

Results: The mean IR was 1.5 (1.0). Individuals with MS, higher body mass index and CRP ≥6 mg/l had higher IR. Linear regression showed, among the components of MS, waist circumference had the highest contribution toward IR. The optimal cut-off value to detect IR by HOMA2-IR was 1.35.

Conclusion: IR was found to have a strong association with various clinico-metabolic risk factors.

Keywords: C-reactive protein, Homeostatic model assessment insulin resistance, Insulin resistance, Metabolic syndrome