Haematological Indices, Blood glucose levels and lipid profile of rats administered Tartrazine E102

Abstract

This work was done as a part of safety assessment to determine the effects of Tartrazine E102 on some haematological indices, glucose levels and blood lipid profile in rats. An animal model was used as a basis for interpreting the situation in humans. Consequently, 40 albino rats were divided into 5 groups of 8 rats each. All the animals were fed rats’ mash and water and administered 0, 10, 20, 40 and 80mg/kg body weight of Tartrazine E102 respectively. Weekly measurements of body weight were recorded. Results obtained showed a significant reduction in body weight gain and blood glucose levels compared with the control. A non-dose dependent effect was observed on total cholesterol, LDL cholesterol, total white blood cells and monocytes. A slight but significant increase was observed in haematocrit at the highest dose levels. Conclusively, Tartrazine E102 exhibited a hypoglycemic effect in rats, no negative effect was observed on lipid profile.

KEY WORDS: Tartrazine E102; glucose; haematological; cholesterol; triacylglycerol