Correlation of Serum PSA and Gleason Score in Nigerian Men with Prostate Cancer

Abstract

Objective: Prostate cancer is an important cause of morbidity and mortality worldwide. While the predisposing factors are not fully understood, African descent is an important risk factor, and prostate cancer has become the number-one cancer in Nigerian men. This was a retrospective study of the correlation between serum prostate specifi c antigen (PSA) and Gleason grade and score in patients of Nigerian descent. Patients and Methods: The University College Hospital (UCH) Ibadan Cancer Registry was used to identify and quantify the incidence of prostate cancers occurring between 1998 and 2000. The histological slides of appropriate cases were reviewed to confi rm the Gleason grade and
score. The serum PSA values were retrieved from the patients\' case notes and laboratory files. The data obtained were subjected to statistical analysis to look for associations and correlations. Results: The study included 67 men with prostate adenocarcinoma and PSA measurements who were diagnosed and treated at the UCH Ibadan between January 1998 and December 2000. There was a positive correlation between serum PSA and Gleason grade, as well as between serum PSA and Gleason score in our cohort of Nigerian African men with prostate cancer. PSA levels were significantly lower in patients with stage B disease than in patients with stage D disease. Conclusion: Serum PSA is signifi cantly higher in metastatic than in localized disease. Further studies are necessary to determine biomarkers that complement serum PSA and the Gleason grading system in the prognostication of prostate cancer in African patients


African Journal of Urology Vol. 14 (1) 2008: pp. 15-22