Evaluation of pyracantha crenulata roem for antiurolithogenic activity in albino rats

Abstract

Objective: The aim of the present study was to investigate the effect of juice extract and alcohol extract of fruit of Pyracantha crenulata (D.Don) Roem  (Rosaceae) against ethylene glycolinduced urolithiasis in male albino rats. Patients and Methods: Lithiasis was induced in rats by administering 0.75% ethylene glycol in drinking water for 28 days and was manifested by hyperoxaluria as well as increased renal excretion of calcium, phosphate and a low urinary magnesium content. Curative and preventive treatment was then tried by supplementation with juice and alcohol extracts (250 mg/kg b.w., p.o.) of P. crenulata fruit. Results: The increased deposition of stone forming constituents in the kidneys of calculogenic rats was significantly lowered by curative and preventive treatment using juice and alcohol extracts (250 mg/kg b.w., p.o.) of P. crenulata fruit which showed a regulatory action on endogenous oxalate synthesis.
Conclusion: From this study, we conclude that both prophylactic and therapeutic treatment with juice and alcohol extract of fruit of P. crenulata may reduce precipitation of calcium oxalate, with improvement of kidney function as well as cytoprotective effect

Keywords : Ethylene glycol, hyperoxaluria, nephrolithiasis, Pyracantha crenulata