Case report: A Stauffer’s syndrome variant associated with renal cell carcinoma and thrombocytopenia

Abstract

Stauffer’s syndrome is a rare paraneoplastic manifestation of renal cell carcinoma which is characterized by elevated alkaline phosphatase, erythrocyte  sedimentation rate, -2-globulin, -glutamyl transferase,  thrombocytosis, prolongation of prothrombin time and hepatosplenomegaly, in the absence of hepatic  metastasis and jaundice. In this case report, we report a patient who was admitted with fever, fatigue,  abdominal pain, weight loss and pruritus in whom renal cell carcinoma was incidentally found in the right kidney during an initial workup.

KEYWORDS: Cholestasis; Paraneoplastic syndrome; RCC; Stauffer’s syndrome; Thrombocytopenia