Article Sidebar
Published:
Jun 14, 2013Keywords:
Article Details
Copyright: Creative Commons Attribution CC.
This license lets others distribute, remix, tweak, and build upon your work, even commercially, as long as they credit you for the original creation. This is the most accommodating of licenses offered. Recommended for maximum dissemination and use of licensed materials. View License Deed | View Legal Code Authors can also self-archive their manuscripts immediately and enable public access from their institution's repository. This is the version that has been accepted for publication and which typically includes author-incorporated changes suggested during submission, peer review and in editor-author communications.
Main Article Content
The effects of β-elemene on the expression of mTOR, HIF-1α, surviving in lung adenocarcinoma A549 cell
Abstract
The purpose of this manuscript was to study the regulation effects of â-elemene combined with radiotherapy on three different gene expressions in lung adenocarcinoma A549 cell. mTOR gene, HIF-1á gene, Survivin gene were included in the gene group. Cell culture and RT-PCR were applied to finish this research. Hypoxia Control group, Hypoxia â-elemene group, Hypoxia â-elemene combined with irradiation group were set to compare the differences of three different gene expressions. The most active effects were found in the group of Hypoxia irradiation combined with â-elemene. In this group, the mTOR gene, HIF-1á gene, Survivin gene expressions were all down-regulated when compared with the single treatment groups, and
there were significantly statistical differences.
Key words: â-elemene, A549, mTOR, HIF-1á, Survivin, Rhizoma Curcumae.
