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Published:
May 7, 2013Keywords:
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Study on anti-tumor effect of total glycosides from radix paeoniae rubra in s180 tumor-bearing mice
Abstract
The objective of the paper was to study the anti-tumor effect of total glycosides from Radix paeoniae rubra in S180 tumor-bearing mice, and to preliminarily explore its mechanism of action. Mice were made into S180 solid tumor model, grouped and administered with the extracts; tumor inhibition rate was measured by harvesting the tumors, and serum IL-2 and IL-4 levels were measured by taking blood samples. Total glycosides of Radix paeoniae
rubra significantly inhibited the growth of tumor cells in tumor-bearing organisms, enhanced the cytotoxic activity of NK cells, and increased the serum IL-2 and IL-4 levels. Total glycosides of Radix paeoniae rubra have
some anti-tumor effect in vivo, which might have been accomplished through the regulation of the immune system.
Keywords: total glycosides of Radix Paeoniae Rubra, S180 sarcoma, IL-2, IL-4
