Article Sidebar
Published:
Oct 20, 2008Keywords:
Antioxidant defence system - Lead acetate - Lipid peroxidation - Red Blood Cell – Rat - Wormwood
Article Details
Issue
Section
Articles
Copyright: Creative Commons Attribution CC.
This license lets others distribute, remix, tweak, and build upon your work, even commercially, as long as they credit you for the original creation. This is the most accommodating of licenses offered. Recommended for maximum dissemination and use of licensed materials. View License Deed | View Legal Code Authors can also self-archive their manuscripts immediately and enable public access from their institution's repository. This is the version that has been accepted for publication and which typically includes author-incorporated changes suggested during submission, peer review and in editor-author communications.
Main Article Content
Role Of Wormwood (Artemisia absinthium) Extract On Oxidative Stress In Ameliorating Lead Induced Haematotoxicity.
Abstract
Effects of ROS generation have been postulated to be major contributors to lead-exposure related disease. The aim of the study was to investigate the effect of aqueous extract of wormwood (Artemisia absinthium) on oxidative stress in rats protractedly exposed to lead. Aqueous extract of wormwood plant was administered orally (200 mg.kg-1 body weight). Plasma vitamin C, E and non-protein thiol concentrations, red blood cells (RBC)
thiobarbituric acid reactive substances, reduced glutathione levels and haemolysis test were evaluated. In addition, RBC antioxidant enzymes activities such as superoxide dismutases, catalase, glutathione peroxidase, glutathione reductase were also estimated. After 11-weeks, significant decreases of plasma vitamin C, E, non protein-thiol (NPSH)
and RBC-reduced glutathione levels were observed in Pb compared to control group (-32.9%, -57.1%, -53.1%, -33.9%, respectively); superoxide dismutase, glutathione peroxidase, uric aminolevulinic acid and haemolysis test significantly increased in Pb compared to control group (+64.3%, +40.3%, +145%, +44.3%, respectively). In our
investigation, after 4-weeks of treatment all treated groups did not show any difference compared to the control group, except for glutathione peroxidase and RBC-superoxide dismutase activity (-15.7% and +16.4%, respectively). The findings of this study suggest that wormwood (Artemisia absinthium) extract restored the enzymes activities
perturbed by exposure to lead. and had a protective role against lipid peroxidation
Keywords: Antioxidant defence system - Lead acetate - Lipid peroxidation - Red Blood Cell – Rat - Wormwood (Artemisia absinthium) plant extract.
African Journal of Trad, Comp and Alternative Medicine Vol. 5 (3) 2008: pp. 263-270
