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Keywords:
i>Hippocratea indica</i> <i>Poga oleosa</i> anti-inflammatory antimicrobial
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Anti-Inflammatory And Antimicrobial Activities Of Hippocratea indica Root Bark And Poga oleosa Fruits
Abstract
The methanolic extracts of Hippocratea indica root bark and Poga oleosa fruits were investigated for anti-inflammatory and antimicrobial activities. Both extracts inhibited carrageenan-induced paw oedema significantly in rats in a dose-dependent manner in 4 h. H. indica inhibited oedema significantly at the minimal dose (125 mg/ml, p< 0.05) from 2 h onward, and gave 100% inhibition in 4 h. at 250 mg/kg. It was shown to be a more potent anti-inflammatory agent than P. oleosa. Also, H. indica extract exhibited greater antimicrobial activity against tested bacteria, with Staphylococcus aureus being the most susceptible bacterium (MIC, 16 mg/ml). Both plants were inactive against Candida albicans. These results confirm the anti-inflammatory and antibacterial activities of the two plants.
Keywords: Hippocratea indica, Poga oleosa, anti-inflammatory, antimicrobial
African Journal of Traditional and Complementary Medicine Vol. 4 (3) 2007: pp. 372-376
