Article Sidebar
Published:
Oct 14, 2008Keywords:
Andrographis paniculata Ness andrographolide TD-47 cell apoptosis.
Article Details
Issue
Section
Articles
Copyright: Creative Commons Attribution CC.
This license lets others distribute, remix, tweak, and build upon your work, even commercially, as long as they credit you for the original creation. This is the most accommodating of licenses offered. Recommended for maximum dissemination and use of licensed materials. View License Deed | View Legal Code Authors can also self-archive their manuscripts immediately and enable public access from their institution's repository. This is the version that has been accepted for publication and which typically includes author-incorporated changes suggested during submission, peer review and in editor-author communications.
Main Article Content
Apoptosis Inducing Effect Of Andrographolide On TF-47 Human Breast Cancer Cell Line
Abstract
Andrographolide isolated from Andrographis paniculata Ness (Acanthaceae) at 0.35 mM , 0.70 mM and 1.40 mM induced DNA fragmentation and increased the percentage of apoptotic cells when TD-47 human breast cancer cell line was treated for 24 , 48 and 72 h. The results demonstrated that andrographolide can induce apoptosis in TD-47 human breast cancer cell line in a time and concentration-dependent manner by increase expression of p53, bax , caspase-3 and decrease expression of bcl-2 determined by immunohistochemical analysis.
Keywords: Andrographis paniculata Ness , andrographolide, TD-47 cell , apoptosis.
African Journal of Traditional and Complementary Medicine Vol. 4 (3) 2007: pp. 345-351
