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Short Communication: The antiulcer effects of the methanol extract of the leaves of Aspilia africana (Asteraceae) in rats
Abstract
Aspilia Africana (Asteraceae) is a plant currently used in Cameroon ethnomedicine for the treatment of stomach ailments. The methanol extract of the leaves of A. africana was investigated against gastric ulcerations induced by HCl/ethanol and pylorus-ligation. With both methods, the extract inhibited gastric ulcerations in a dose-related manner. Oral administration of the plant extract at the doses of 0.5 and 1 g/kg reduced gastric lesions induced by HCl/ethanol by 79% and 97% respectively. The extract at the dose of 1 g/kg reduced gastric lesion in the pylorus ligated rats by 52% although the gastric acidity remained higher as compared to the control. These findings show that methanol extract of the leaves of A. Africana possess potent antiulcer properties.
Key words: Aspilia Africana, antiulcer, rat
Afr. J. Trad. Comp. Alt. Med. Vol.2(3) 2005: 233 - 237
Key words: Aspilia Africana, antiulcer, rat
Afr. J. Trad. Comp. Alt. Med. Vol.2(3) 2005: 233 - 237
