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Published:
Mar 22, 2005Keywords:
Bridelia ndellensis hypoglycemic effect Streptozotocin diabetes rats
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Antihyperglycemic effect of Bridelia ndellensis ethanol extract and fractions in Streptozotocin-induced diabetic Rats
Abstract
The effects of the ethanol extract (1.25 g/kg) and fractions (1 g/kg) of Bridelia ndellensis stem bark on the blood glucose levels in streptozotocin-induced types 1 and 2 diabetic rats at different prandial states were studied. The ethanol extract of B. ndellensis had no hypoglycemic effect in type 1 diabetic rats in fasting and postprandial glucose load conditions and, in type 2 diabetic rats in fasting condition. However, the extract, and its ethyl acetate and dichloromethane fractions significantly lowered blood glucose levels in type 2 diabetic rats when fed simultaneously with glucose. The active principles responsible for the antihyperglycaemic effect are concentrated in the ethyl acetate and dichloromethane fractions of the extract.
Key Words: Bridelia ndellensis; hypoglycemic effect; Streptozotocin; diabetes; rats.
Afr. J. Trad. CAM (2005) 2 (2): 94 - 102
Key Words: Bridelia ndellensis; hypoglycemic effect; Streptozotocin; diabetes; rats.
Afr. J. Trad. CAM (2005) 2 (2): 94 - 102
