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Published:
Feb 20, 2017Keywords:
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Inhibition of paclitaxel against neuroglioma cells U251 growth and its mechanism
Abstract
Background: Glioma is the most common primary tumor of the central nervous system, and accounted for about 70% of primary tumors.
Materials and Methods: In the study, antitumour activity and mechanism of paclitaxel was investigated. Different concentrations of paclitaxel (200, 300, 400 μmol/L) was treated in neuroglioma cellsU251.
Results: Paclitaxel significantly inhibited neuroglioma cells growth, and promoted its apoptosis. Paclitaxel can block tumour cells in the G2/M phase. In addition, apoptosis-related genes caspase-3 and bax expressions were increased after paclitaxel treatment.
Conclusion: Our work indicated that paclitaxel displayed strong anti-tumour activity.
Keywords: paclitaxel, antitumour, apoptosis, cell cycle
